Salts in Biopharma Downstream - Enhancing Process Efficiency and Product Quality

• Buffer Solutions: Mineral Salts, such as Phosphate salts (e.g. Sodium Phosphate or Potassium Phosphate), are commonly used to prepare buffer solutions. These maintain a stable pH level during downstream processing, which is crucial for the stability and activity of biological molecules and enzymes.
•  Ion Exchange Chromatography: Ion exchange chromatography is a common technique in downstream processing. During elution, salts displace bound molecules from the resin by competing for ionic binding sites. The type and concentration of Salts, such as Sodium Chloride or Potassium Chloride, determine the efficiency and selectivity of molecule separation. In biopharma, these salt-based buffer solutions stabilize the process and protect sensitive biomolecules. Precise salt dosing prevents unwanted interactions or protein aggregation, ensuring the purity and efficacy of the final product.
• Salting-Out: Salting-out is a method that uses high concentrations of Salt (often Ammonium Sulfate) to reduce the solubility of proteins or other molecules. This can facilitate their separation and purification.

The specific Mineral Salts used in downstream processing depend on the nature of the product being processed, the required conditions, and the purification methods employed. It is essential to choose the appropriate salts and concentrations carefully to optimize the downstream processes and achieve the desired results.
Leveraging our expertise in Mineral Salt manufacturing, we offer our customers a wide range of options for functional optimization, helping them tailor their downstream processes for maximum efficiency and quality.